Research Explorer

Your browser does not support JavaScript or JavaScript is not enabled. Without JavaScript some functions of this webapplication may be disabled or cause error messages. To enable JavaScript, please consult the manual of your browser or contact your system administrator.

Researcher

Adriaan Verhelle

Awards & Distinctions

12 Results

2023

Variational autoencoders to predict DNA-methylation age and provide biological insights in age-related health and disease

Sandra SteyaertAdriaan VerhelleWim Van Criekinge

2018

Intracellular displacement of p53 using transactivation domain (p53 TAD) specific nanobodies

Anneleen SteelsAdriaan VerhelleOlivier ZwaenepoelJan Gettemans

A1 Journal Article in MABS

Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells

Laurence BertierTim HebbrechtElien MettepenningenNatasja De WitOlivier ZwaenepoelAdriaan VerhelleJan Gettemans

A1 Journal Article in BIOMEDICINE & PHARMACOTHERAPY

2017

AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

Adriaan VerhelleNair NishaInge EveraertWouter Van OverbekeLynn SupplyOlivier ZwaenepoelCindy PelemanJo Van DorpeTony LahoutteNick Devoogdt et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Gelsolin amyloidosis : a diagnostic and therapeutic nanobody approach

Adriaan VerhelleJan Gettemans

VCA nanobodies target N-WASp to reduce invadopodium formation and functioning

Tim HebbrechtIsabel Van AudenhoveOlivier ZwaenepoelAdriaan VerhelleJan Gettemans

A1 Journal Article in PLOS ONE

2016

A nanobody‐based approach to amyloid diseases, the gelsolin case study

Adriaan VerhelleJan Gettemans

Bookchapter in Exploring new findings on amyloidosis

A new survivin tracer tracks, delocalizes and captures endogenous survivin at different subcellular locations and in distinct organelles

Els BegheinIsabel Van AudenhoveOlivier ZwaenepoelAdriaan VerhelleAriane De GanckJan Gettemans

A1 Journal Article in SCIENTIFIC REPORTS

Non-invasive imaging of amyloid deposits in a mouse model of AGel using 99mTc-modified nanobodies and SPECT/CT

Adriaan VerhelleWouter Van OverbekeCindy PelemanRebecca De SmetOlivier ZwaenepoelTony LahoutteJo Van DorpeNick DevoogdtJan Gettemans

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

2015

An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model

Wouter Van OverbekeJantana WongsantichonInge EveraertAdriaan VerhelleOlivier ZwaenepoelAnantasak LoonchantaLeslie D BurtnickAriane De GanckTino HochepiedJody Haigh et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

2014

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture

Jonas BethuyneSteven De GieterOlivier ZwaenepoelAbel Garcia-PinoKaat DurinckAdriaan VerhelleGholamreza Hassanzadeh-GhassabehFranki SpelemanRemy LorisJan Gettemans

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model

Wouter Van OverbekeAdriaan VerhelleInge EveraertOlivier ZwaenepoelJoël VandekerckhoveClaude CuvelierWim DeraveJan Gettemans

A1 Journal Article in MOLECULAR THERAPY